Nonhuman Primate Calorie Restriction

Calorie restriction and aging in nonhuman primates.

In the 75 years since the seminal observation of Clive McCay that restriction of calorie intake extends the lifespan of rats, a great deal has been learned about the effects of calorie restriction (CR; reduced intake of a nutritious diet) on aging in various short-lived animal models. Studies have demonstrated many beneficial effects of CR on health, the rate of aging, and longevity. Two prospe...

Calorie Restriction, Longevity and Cognitive Function

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

Nonhuman Primate Ocular Biometry

PURPOSE To examine ocular growth in nonhuman primates (NHPs) from measurements on ex vivo eyes. METHODS We obtained NHP eyes from animals that had been killed as part of other studies or because of health-related issues. Digital calipers were used to measure the horizontal, vertical, and anteroposterior globe diameters as well as corneal horizontal and vertical diameters of excised globes fro...

Calorie Restriction à Lamarck

Epigenetic inheritance of resistance to exogenous nucleic acids via small interfering (si) RNA is well established in animal models. Rechavi et al. demonstrate epigenetic inheritance of a starvation-induced pattern of gene silencing caused by endogenous siRNAs and resulting in an increased longevity in the third generation progeny. Combined with recent findings in prokaryotes, these results sug...